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The leading cause of mesothelioma and malignant mesothelioma cancer is generally accepted to be exposure to asbestos. However, there are cases in a which a person with no known exposure to asbestos have developed mesothelioma. There have also been incidents in which patients receiving radiation treatment for other cancers have later developed mesothelioma in the areas - or areas adjacent to - where they had been irradiated. Despite all of these things, asbestos is largely considered to be the leading cause of mesothelioma.
Also, the duration of a persons exposure to asbestos seems to factor little in either heightening or lowering their chance of developing malignant mesothelioma. There are cases in which a person - having only been exposed to asbestos for one to three months - has developed malignant mesothelioma with no clear cause other than their limited exposure to asbestos.
In closing, the easiest and most efficient way to ease your mind about mesothelioma is to maintain a clean and safe environment which does not cater to the lead mesothelioma cause - asbestos.